Dr. Elad Anter

The focus of my career is the study of arrhythmia mechanisms utilizing physiologically relevant large animal models. This research is stimulated by a clinical practice focused on treating patients with complex arrhythmias, particularly those who had failed standard therapies. My research laboratory develops animal models of human-like rhythm disorders with a particular focus on ventricular tachycardia and ventricular fibrillation, for which current treatment options are limited and/or suboptimal. These models are created by selective balloon occlusion of one or more coronary arteries resulting in structural and electrical ventricular remodeling (i.e., “arrhythmogenic substrate”) and subsequent development of arrhythmias. Models for atrial arrhythmias, including atrial tachycardia and fibrillation are created by ablation-induced scar formation which promotes the development of these arrhythmias. Animals are survived for variable periods, allowing them to study the natural history